Primary Cilia: Putting Sensors Together
نویسنده
چکیده
Primary cilia extend like antennae from the surface of most eukaryotic cells into the environment, where they function in a variety of sensory roles. Recent studies reveal an intimate interplay between structural proteins of the centrosome and the formation of primary cilia, and provide new insight into the complex function of these fascinating organelles.
منابع مشابه
Primary Cilia: Highly Sophisticated Biological Sensors
Primary cilia, thin hair-like structures protruding from the apical surface of most mammalian cells, have gained the attention of many researchers over the past decade. Primary cilia are microtubule-filled sensory organelles that are enclosed within the ciliary membrane. They originate at the cell surface from the mother centriole that becomes the mature basal body. In this review, we will disc...
متن کاملPrimary Cilia in the Breast and Breast Cancer
Primary cilia are non-motile, microtubule-based appendages extending from the surfaces of most vertebrate cells. The function of primary cilia is cell-type dependent. However, they are known to serve as sensors of the extracellular environment by sensing mechanical forces and chemical constituents in several different cell types. They also function as critical platforms for several signaling pa...
متن کاملPrimary cilia and kidney injury: current research status and future perspectives.
Cilia, membrane-enclosed organelles protruding from the apical side of cells, can be divided into two classes: motile and primary cilia. During the past decades, motile cilia have been intensively studied. However, it was not until the 1990s that people began to realize the importance of primary cilia as cellular-specific sensors, particularly in kidney tubular epithelial cells. Furthermore, ac...
متن کاملEndothelial primary cilia inhibit atherosclerosis.
Primary cilia are microtubule-based structures present on most mammalian cells that are important for intercellular signaling. Cilia are present on a subset of endothelial cells where they project into the vessel lumen and are implicated as mechanical sensors of blood flow. To test the in vivo role of endothelial cilia, we conditionally deleted Ift88, a gene required for ciliogenesis, in endoth...
متن کاملPrimary cilia: cellular sensors for the skeleton.
The primary cilium is a solitary, immotile cilium that is present in almost every mammalian cell type. Primary cilia are thought to function as chemosensors, mechanosensors, or both, depending on cell type, and have been linked to several developmental signaling pathways. Primary cilium malfunction has been implicated in several human diseases, the symptoms of which include vision and hearing l...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current Biology
دوره 14 شماره
صفحات -
تاریخ انتشار 2004